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Tyranny of the Gene : Personalized Medicine and Its Threat to Public Health
Knopf Publishing Group
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336page/159*245*31/685g
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9780525658207/0525658203
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  • ¡°Incisive . . . Tabery is a penetrating critic, positing that research on personalized drugs takes up an oversize share of funding because it¡¯s more profitable than investigating environmental determinants of health. . . . This damning take on scientific bias is not to be missed.¡±¡ªPublishers Weekly (starred review) ¡°An accessible narrative bolstered by prodigious research . . . An engaging, provocative study of a much-hyped aspect of American health care . . . Tabery succeeds in raising a compelling alarm about where things stand and making clear that the current situation could have been much different, all while laying the groundwork for an alternative future.¡±¡ªKirkus Reviews ¡°The majority of the common diseases that take a large toll on health in America are caused by lifestyle and environmental factors, or those factors combined with genetics. Yet biomedical research today is focused on genes and exorbitantly expensive gene-based therapies¡ªto the detriment of our health and our pocketbooks. In this powerful book, James Tabery explains how and why the promise of ¡®personalized¡¯ and ¡®precision¡¯ medicine has failed us. A must-read for doctors, patients, scientists, and anyone who cares about the future of health in America.¡±¡ªNaomi Oreskes, co-author of Merchants of Doubt: How a Handful of Scientists Obscured the Truth on Issues from Tobacco Smoke to Global Warming ¡°James Tabery¡¯s book makes the case for why the revolutionary promise of precision medicine has been, at best, elusive and, at worst, a distraction from the revolution we truly need: a radical reimagining of how we prevent disease in our society.¡±¡ªSandro Galea, author of Well: What We Need to Talk About When We Talk About Health ¡°Tyranny of the Gene is an extraordinary and invaluable investigation into the prevailing fashions of twenty-first-century medical research, and the price we may be paying for the very questionable promise of personalized medicine.¡±¡ªGary Taubes, author of Why We Get Fat ¡°We have long known that the best way to improve the nation¡¯s health is to clean up the environment and enhance social equality. Instead, as Tyranny of the Gene brilliantly shows, we are investing in gene-based personalized medicine, catering to the most privileged patients and enriching pharmaceutical companies. By unraveling the financial, political, and scientific history of hyping genetics¡¯ failed promises, Tabery makes a compelling case for changing course toward a healthier future for all.¡±¡ªDorothy Roberts, author of Fatal Invention: How Science, Politics, and Big Business Re-create Race in the Twenty-first Century ¡°Tyranny of the Gene will challenge your thinking about the ¡®miracle cures¡¯ of DNA-based personalized medicine. In documenting the rise of genetically-based treatments, Tabery reveals the scientific, financial and political forces that have promoted this technology ¡ª much to the detriment of health care equality and public health research. Deeply investigated and fluidly to...
  • 1 A Tale of Two Revolutions Olga Owens Huckins and her husband, Stuart, had cultivated a two-acre oasis about thirty-five miles southeast of Boston on the Powder Point peninsula of Duxbury, Massachusetts. They¡¯d left a large portion of it to wilderness, where reeds grew thick in freshwater ponds and mature cedars and oaks abounded. Just off the coast of Duxbury Bay, their refuge was a perfect spot for migrating birds to feed, rest, and nest. Olga and Stuart were bird lovers and welcomed birders onto their property to seek out the night herons and spotted sandpipers, the American goldfinches and Carolina wrens. But on a summer day in 1957, Olga looked out at her beloved bird sanctuary in horror. The ground was filled with the corpses of birds, their beaks open but silent and their tiny claws scrunched up to their chests in anguish. Days earlier, a crop duster hired by the State of Massachusetts to spray a pesticide aimed at exterminating mosquitoes had crisscrossed the Huckinses¡¯ sanctuary. The chemical, DDT (dichlorodiphenyltrichloroethane), killed indiscriminately. The couple found seven songbirds dead almost immediately. The next day three more lay lifeless around their birdbath. The day after that they watched a robin drop off a branch. The bees and grasshoppers were also killed off. Ironically, it seemed as if only the mosquitoes survived. When, in January 1958, Olga read in The Boston Herald assurances from a representative of the State of Massachusetts spraying program that the pesticide they were continuing to release was safe and effective, she wrote a letter to the paper describing the devastation to her property and the wildlife that lived on it, as well as the deep betrayal she felt. ¡°They were birds that lived close to us, trusted us, and built their nests in our trees year after year.¡± No one, she said, could witness the impact of that pesticide and deem it harmless to all but mosquitoes. Olga also sent a copy of her letter to a friend who had worked for the U.S. Fish and Wildlife Service. Was there anyone who could help halt the spraying of DDT? That friend was Rachel Carson. By 1958, Carson was well aware of the threat posed by DDT. In fact, in 1945, when she was working for the Fish and Wildlife Service, she¡¯d reached out to Reader¡¯s Digest to see if it would be interested in a story about the DDT testing that the service was conducting. DDT was hailed as a miracle of modern science, used widely by the American military during World War II, sprayed across islands in the Pacific to kill malaria-carrying mosquitoes, and doused on soldiers in Europe to kill typhus-carrying lice. After the war, DDT came to represent the Cold War mentality of humans triumphing over nature. In contrast to previous synthetic pesticides that tended to work only on certain pests, DDT promised to eradicate all sorts of vermin; what¡¯s more, the chemical compound was cheap and stayed in soil and on plants for extended periods, so it continued to repel in...
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