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전공도서/대학교재

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의약학간호계열

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• 제휴몰 주문 시 고객보상, 일부 이벤트 참여 및 증정품 증정, 하루/당일 배송에서 제외되므로 참고 바랍니다.

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• 도서  > 전공도서/대학교재  > 의약학간호계열

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• “이 책은 노화란 무엇인가에 대한 두 번째 응답이다. 첫 번째 응답은 노화의 원인을 분자생물학적으로 밝히는 ‘노화의 생물학’에서 하였으며, 두 번째 응답으로 노화와 관련된 인체의 변화를 ‘노화생리학’에 담고 있다.” 노화란 무엇인가? 어린 아이가 태어나서 키가 자라 성인이 되듯이 노화가 일어나는 현상도 인간의 발달과정의 하나라고 생각할 수 있다. 노화 자체가 질병은 아니지만 노화가 일어나면서 질병을 가질 확률은 점점 더 증가해간다. 노화를 일으키는 원인에 대해서도 우리의 유전자 안에 수명을 결정하는 프로그램이 짜여 있다는 프로그램설과 우리가 살아가면서 손상을 받는 것이 축적되어 일어난다는 에러설 등 수많은 학설이 존재한다. 조지 윌리암스라는 학자는 어떤 유전자가 생명의 초기에는 유익한 영향을 주다가 생명의 후기에는 해로운 영향을 줄 수 있다는 대립적 다면발현(antagonistic pleiotropy) 이론을 주장하였다. 종양 억제 유전자나 염증 반응 등은 생명의 초기에는 생명체를 보호하는데 강력한 힘을 발휘하지만 생명의 후반부에서는 오히려 노화를 촉진하거나 병적인 상태를 촉진하는 요인으로 작용한다. 따라서 이러한 노화 촉진 인자의 존재는 노화를 일으키는 필수불가결의 요소로 작용하게 되는 것이다. 그런데 진화에 의하여 이와 같은 해로운 인자가 제거되지 않는 이유는 그들이 인생의 전반기에 발휘하는 강력한 생명체 보호작용이 노화를 일으키는 해로운 역할을 능가하기 때문에 선택받을 수 있었던 것이다. 본 노화생리학에서는 생명체에서 노화하면서 일어나는 생리적 기능의 변화에 대하여 알아보고자 하였다. 이러한 고찰은 초고령 사회로 전이하는 현 상황에서 필요한 일이라 생각되며 이러한 과정을 통하여 보다 더 건강한 사회로의 진행에 도움이 될 것으로 생각한다.
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• 이 책은 노화에 지속적인 관심을 기울여온 오상진 교수와 30여 년간 인체생리학을 연구한 임욱빈 교수가 힘을 합해 만든 노화에 대한 생리학적 접근이다. 오상진 교수의 지난 저서 “노화의 생물학”은 노화가 일어나는 원인을 분자생물학적 접근으로 다각적으로 다루고 있다면, 이 “노화 생리학”은 인체의 각 기관이 노화되면서 발생하는 현상과 그에 따르는 질병 등에 대해 다루고 있다. 특히 책의 후반부 8장에서 치매와 관련된 질환을, 9장에서 암을 다룸으로써 대한민국에서 많이 발생하는 노령 질환에 대해 심도 있게 서술하고 있다. 그와 함께 노화와 함께 오는 요실금, 탈모, 근육에 관한 이해 등을 다루고 있다. 따라서 이 책은 노화에 대해서 생리학이라는 학술적 접근을 할 뿐만 아니라 일반 대중에게도 어필할 수 있는 노화 관련 지식과 질환에 대해서 풀어내고 있다. 이 책은 전공자들에게는 노화에 대한 교재로 쓸 수 있고, 인체 노화와 그 질환에 관심이 있는 일반인들은 노화 현상과 그 질환에 대한 전문 지식을 높이는 데 큰 도움이 될 것이다.
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• 머리말 5 1 항상성과 노화｜13 1절 노화와 항상성 협착(homeostenosis) / 13 1) 항상성············································································································ 13 2) 변상성············································································································ 15 3) 생리적 예비 역량····························································································· 16 4) 노화와 내재 역량의 저하 ················································································· 17 2절 체온조절과 노화 / 20 1) 체온조절의 개요······························································································· 20 2) 체온의 항상성 기구························································ ································· 23 3) 열의 보존과 열생산·························································· ······························· 25 4) 열의 발산····························································...············································ 27 5) 온도감각과 체온조절 기능의 노화······································································· 28 2 근골격계와 노화｜35 1절 골격계 / 36 1) 골격계의 구조와 기능······················································································· 36 2) 뼈의 구조와 형성····························································································· 37 3) 뼈의 노화－골감소증과 골다공증·········································································40 4) 뼈를 튼튼하게 하는 방법··················································································· 42 2절 운동능력과 근육의 노화 / 44 1) 근육의 종류－골격근, 평활근, 심근·······································································44 2) 골격근의 수축·································································································· 46 3) 근육의 수축과 장력의 크기················································································ 47 4) 골격근의 기능과 운동에서 기타 기관의 역할························································ 48 5) 근육감소증······································································································· 52 6) 근력감소증······································································································· 56 7) 근육의 조성 변화······························································································ 57 8) 운동이 근육과 기타 기관의 기능에 미치는 효과···················································· 63 3 심혈관계와 노화｜67 1절 순환계의 구조와 기능 / 67 1) 순환계와 기타 기관과의 협동 관계 ···································································· 69 2) 순환계의 구성·································································································· 69 3) 혈압 조절········································································································ 82 4) 각 기관으로의 혈류량의 조절············································································· 88 2절. 심혈관계의 노화 / 92 1) 심장 구조의 변화······························································································ 93 2) 심장 세포의 변화······························································································ 94 3) 심장박동수의 감소···························································································· 95 4) 심장의 수축력의 약화 ······················································································ 96 5) 심장의 적응 보상과 생리적 역량의 감소 ····························································· 97 6) 동맥의 구조와 혈압의 변화··············································································· 103 7) 모세혈관의 변화 ···························································································· 104 8) 정맥의 변화 ·································································································· 105 9) 노화와 관련된 혈액의 변화··············································································· 106 4 내분비계와 노화｜109 1절 내분비계의 개요 / 109 1) 내분비계의 특징······························································································ 110 2) 사람의 내분비선······························································································ 114 2절 노화에 따른 내분비계의 변화 / 126 1) 성장호르몬과 노화··························································································· 128 2) 인슐린유사성장인자와 노화··············································································· 131 3) 인슐린과 노화································································································· 132 4) 칼슘대사와 노화······························································································ 136 5) 코티졸과 노화································································································· 138 6) DHEA와 노화································································································· 142 7 ) 성호르몬과 노화···························································································· 143 5 비뇨기계와 노화｜145 1절 비뇨기계의 구성과 하는 역할 / 145 1) 비뇨기계의 기능과 체액환경············································································· 147 2) 콩팥의 구조와 기능························································································· 150 3) 네프론은 콩팥의 기능적 단위이다······································································ 152 2절 오줌의 형성과정 / 153 1) 사구체 여과···································································································· 153 2) 세뇨관 재흡수································································································· 158 3) 세뇨관 분비···································································································· 163 4) 오줌의 농축기작······························································································ 164 5) 오줌의 저장 및 배뇨························································································ 168 3절 콩팥 생리 / 171 1) 콩팥 기능 평가······························································································· 172 2) 수분 재흡수 조절···························································································· 174 3) 나트륨 재흡수 조절························································································· 175 4) 산－염기 평형 ······························································································· 178 4절 노화에 따른 비뇨기계의 변화 / 178 1) 콩팥·············································································································· 178 2) 방광·············································································································· 181 3) 요도·············································································································· 182 5절 노화 연관 비뇨기질환 / 183 1) 만성콩팥병····································································································· 183 2) 체액 및 전해질 대사 이상················································································ 184 3) 요실금··········································································································· 185 4) 전립선 질환···································································································· 186 6 면역계와 노화｜191 1절 면역계의 개요 / 191 1) 면역계의 구성································································································· 192 2) 선천면역········································································································ 201 3) 항체매개 면역반응··························································································· 213 4) T 세포의 발달과 활성····················································································· 216 5) 세포매개 면역반응··························································································· 219 2절 노화에 따른 면역기능의 변화 / 220 1) 흉선의 퇴축···································································································· 221 2) CD4 : CD8 비율의 변화·················································································· 223 3) Naive T 세포의 감소와 Memory T 세포의 증가················································ 223 4) 사이토카인의 변화··························································································· 224 5) 점막면역(mucosal immunity)반응의 감소··························································· 225 6) 노화에 따른 선천면역반응의 변화······································································ 225 7) 노화에 따른 B 세포 수 감소············································································ 226 3절 노화와 염증반응 / 227 7 피부계통의 노화｜231 1절 피부의 노화 / 232 1) 피부의 구조···································································································· 232 2) 피부의 기능···································································································· 240 3) 피부장벽········································································································ 243 4) 피부의 노화···································································································· 246 5) 광노화의 기전································································································· 257 2절 탈모 / 263 1) 모발의 구조 및 특징······················································································· 263 2) 모발의 발생 및 성장························································································ 266 3) 모발 성장주기와 생체시계 유전자의 발현··························································· 269 4) 탈모증··········································································································· 272 8 신경계와 노화｜281 1절 인간 뇌의 구조 / 281 1) 뇌가 기능하는 방식························································································· 281 2) 정서적 뇌의 기능···························································································· 283 3) 신경세포의 역할······························································································ 285 4) 기억은 어떻게 저장되는가················································································ 287 2절 파킨슨병 / 288 1) 파킨슨병의 잠재적 원인··················································································· 289 2) 미토콘드리아 기능장애와 파킨슨병···································································· 291 3) 파킨슨병의 병독성··························································································· 291 3절 알츠하이머병 / 293 1) 알츠하이머병은 신경퇴행성질환이다··································································· 293 2) 알츠하이머병의 증상과 특징 ············································································ 295 3) 알츠하이머병의 진행은 몇 단계로 나눌 수 있다·················································· 297 4절 알츠하이머병의 원인 / 299 1) 콜린작동성 가설······························································································ 300 2) 베타아밀로이드 가설························································································ 300 3) Tau 가설······································································································· 313 4) 베타아밀로이드가 세포를 죽이는 기작 ····························································· 315 5) 미토콘드리아 기능장애····················································································· 317 9 암과 노화｜323 1절 암이란 무엇인가? / 324 1) 양성 및 악성 종양··························································································· 325 2) 암의 구분······································································································· 326 3) 암세포의 특성································································································· 329 4) 암의 원인······································································································· 331 5) 암의 진행단계································································································ 337 2절 암과 유전 / 339 1) 세포증식 억제와 관련된 유전자들····································································· 339 2) DNA 수선과 유전적 안정성에 관여하는 유전자·················································· 341 3절 암유전자 / 344 1) 세포의 암유전자는 어떻게 만들어지는가? ························································· 344 2) 암유전자가 생산한 단백질················································································ 348 4절 종양억제유전자 / 352 1) 세포증식과 세포사멸에서의 기능······································································· 352 2) DNA 수선 및 유전체 안정성에서의 기능···························································· 359 5절 노화하면서 암이 증가하는 이유 / 362 1) 암은 유전자의 변화가 축적되어 발생한다··························································· 362 2) 중장년 이후의 염증성의 미세환경이 암을 촉진할 수 있다··································· 363 3) 노화세포는 유전자 복구시스템도 약화되며 이것은 암을 촉진할 수 있다············ 364 4) 노화에 따른 면역기능의 변화가 암을 촉진할 수 있다········································· 365 6절 한국인의 암 / 365 1) 주요 암 발생 현황··························································································· 365 2) 암 사망률 현황······························································································· 369 3) 암 사망률 30년간 변동 추이············································································· 370 4) 암 생존률······································································································· 371 찾아보기 ?374
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인터파크도서는 고객님의 단순 변심에 의한 교환과 반품에 드는 비용은 고객님이 지불케 됩니다. 단, 상품이나 서비스 자체의 하자로 인한 교환 및 반품은 무료로 반품 됩니다. 교환 및 반품이 가능한 경우 상품을 공급 받은 날로부터 7일이내 가능 공급받으신 상품의 내용이 표시, 광고 내용과 다르거나 다르게 이행된 경우에는 공급받은 날로부터 3개월 이내,    혹은 그사실을 알게 된 날 또는 알 수 있었던 날로부터 30일 이내 상품에 아무런 하자가 없는 경우 소비자의 고객변심에 의한 교환은 상품의 포장상태 등이 전혀 손상되지 않은 경우에 한하여 가능 교환 및 반품이 불가능한 경우 구매확정 이후(오픈마켓상품에 한함) 고객님의 책임 있는 사유로 상품 등이 멸실 또는 훼손된 경우    (단, 상품의 내용을 확인하기 위하여 포장 등을 훼손한 경우는 제외) 시간이 지남에 따라 재판매가 곤란할 정도로 물품의 가치가 떨어진 경우 포장 개봉되어 상품 가치가 훼손된 경우 다배송지의 경우 반품 환불 다배송지의 경우 다른 지역의 반품을 동시에 진행할 수 없습니다. 1개 지역의 반품이 완료된 후 다른 지역 반품을 진행할 수 있으므로, 이점 양해해 주시기 바랍니다. 중고상품의 교환 중고상품은 제한된 재고 내에서 판매가 이루어지므로, 교환은 불가능합니다. 오픈마켓 상품의 환불 오픈마켓상품에 대한 책임은 원칙적으로 업체에게 있으므로, 교환/반품 접수시 반드시 판매자와 협의 후 반품 접수를 하셔야하며,    반품접수 없이 반송하거나, 우편으로 보낼 경우 상품 확인이 어려워 환불이 불가능할 수 있으니 유의하시기 바랍니다.

배송예정일 안내 인터파크 도서는 모든 상품에 대해 배송완료예정일을 웹사이트에 표시하고 있습니다. <인터파크 직배송 상품> 상품은 월~토요일 오전 10시 이전 주문분에 대하여 당일 출고/당일 배송완료를 보장하는 상품입니다. 상품은 서울지역/평일 주문분은 당일 출고/익일 배송완료를 보장하며, 서울외지역/평일 주문분의 경우는 오후 6시까지 주문분에 대하여 익일 배송완료를 보장하는 상품입니다. (단, 월요일은 12시까지 주문에 한함) 상품은, 입고예정일(제품출시일)+택배사배송일(1일)에 배송완료를 보장합니다. ~ 상품은 유통특성상 인터파크에서 재고를 보유하지 않은 상품으로 주문일+기준출고일+택배사배송일(1일)에 배송완료를 보장합니다.(토/공휴일은 배송기간에 포함되지 않습니다.) ※기준출고일:인터파크가 상품을 수급하여 물류창고에서 포장/출고하기까지 소요되는 시간 <업체 직접배송/오픈마켓 상품> ~ 상품은 업체가 주문을 확인하고, 출고하기까지 걸리는 시간입니다. 주문일+기준출고일+택배사배송일(2일)에 배송완료를 보장합니다.(토/공휴일은 배송기간에 포함되지 않습니다.) ※5일이내 출고가 시작되지 않을시, 오픈마켓 상품은 자동으로 주문이 취소되며, 고객님께 품절보상금을 지급해 드립니다. 배송비 안내 도서(중고도서 포함)만 구매하시면 : 배송비 2,000원 (1만원이상 구매 시 무료배송) 음반/DVD만 구매하시면 : 배송비 1,500원 (2만원이상 구매 시 무료배송) 잡지/만화/기프트만 구매하시면 : 배송비 2,000원 (2만원이상 구매 시 무료배송) 도서와 음반/DVD를 함께 구매하시면 : 배송비 1,500원 1만원이상 구매 시 무료배송) 도서와 잡지/만화/기프트/중고직배송상품을 함께 구매하시면 : 2,000원 (1만원이상 구매 시 무료배송) 업체직접배송상품을 구매시 : 업체별로 상이한 배송비 적용    * 세트상품의 경우 부분취소 시 추가 배송비가 부과될 수 있습니다.    * 북카트에서 배송비없애기 버튼을 클릭하셔서, 동일업체상품을 조금 더 구매하시면, 배송비를 절약하실 수 있습니다. 해외배송 안내 인터파크도서에서는 국내에서 주문하시거나 해외에서 주문하여 해외로 배송을 원하실 경우 DHL과 특약으로 책정된 요금표에    의해 개인이 이용하는 경우보다 배송요금을 크게 낮추며 DHL(www.dhl.co.kr)로 해외배송 서비스를 제공합니다. 해외배송은 도서/CD/DVD 상품에 한해 서비스하고 있으며, 다른 상품을 북카트에 함께 담으실 경우 해외배송이 불가합니다. 해외주문배송 서비스는 인터파크 도서 회원 가입을 하셔야만 신청 가능합니다. 알아두세요!!! 도매상 및 제작사 사정에 따라 품절/절판 등의 사유로 취소될 수 있습니다. 오픈마켓업체의 배송지연시 주문이 자동으로 취소될 수 있습니다. 출고가능 시간이 서로 다른 상품을 함께 주문할 경우 출고가능 시간이 가장 긴 기준으로 배송됩니다. 유통의 특성상 출고기간은 예정보다 앞당겨지거나 늦춰질 수 있습니다. 택배사 배송일인 서울 및 수도권은 1~2일, 지방은 2~3일, 도서, 산간, 군부대는 3일 이상의 시간이 소요됩니다.